Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recapitulating development: a template for periodontal tissue engineering.

U Ripamonti1

  • 1Bone Research Unit, Medical Research Council/University of the Witwatersrand, Johannesburg, South Africa. ugo.ripamonti@wits.ac.za

Tissue Engineering
|May 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mass guide for the harvest of cortico-cancellous bone from the posterior iliac crest for mandibular reconstruction.

The British journal of oral & maxillofacial surgery·2019
Same author

New technique for endoscopically-assisted particulate graft reconstruction of the mandible.

The British journal of oral & maxillofacial surgery·2018
Same author

Tissue segregation restores the induction of bone formation by the mammalian transforming growth factor-β(3) in calvarial defects of the non-human primate Papio ursinus.

Biomaterials·2016
Same author

Redefining the induction of periodontal tissue regeneration in primates by the osteogenic proteins of the transforming growth factor-β supergene family.

Journal of periodontal research·2016
Same author

Biological aspects of periodontal tissue regeneration: cementogenesis and the induction of Sharpey's fibres.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2013
Same author

Synergistic induction of periodontal tissue regeneration by binary application of human osteogenic protein-1 and human transforming growth factor-β3 in Class II furcation defects of Papio ursinus.

Journal of periodontal research·2011
Same journal

Change in u.s. Patent infringement law.

Tissue engineering·2009
Same journal

Functional reconstruction of the jaw bones using poly(l-lactide) mesh and autogenic particulate cancellous bone and marrow.

Tissue engineering·2009
Same journal

Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration.

Tissue engineering·2009
Same journal

Cross-linking of gelatin with carbodiimides.

Tissue engineering·2009
Same journal

Early treatment of diabetes with porcine islets in a bioartificial pancreas.

Tissue engineering·2009
Same journal

Permeability of filters used for immunoisolation.

Tissue engineering·2009
See all related articles

Bone morphogenetic proteins (BMPs/OPs) from the TGF-beta superfamily induce new bone formation. Studies in nonhuman primates show these proteins can regenerate complex periodontal tissues, offering therapeutic potential.

Area of Science:

  • Molecular Biology
  • Periodontology
  • Tissue Engineering

Background:

  • Soluble osteogenic molecular signals, particularly the transforming growth factor-beta (TGF-beta) superfamily, are crucial for bone formation.
  • Bone morphogenetic proteins (BMPs/OPs), members of the TGF-beta superfamily, have demonstrated bone induction capacity in preclinical and clinical settings.
  • BMPs/OPs orchestrate de novo endochondral bone formation, mimicking embryonic development and guiding periodontal tissue morphogenesis.

Purpose of the Study:

  • To review the induction of complex periodontal tissue morphologies.
  • To examine the effects of naturally derived and recombinant human BMPs/OPs on furcation defects in nonhuman primates (Papio ursinus).

Main Methods:

  • Review of studies involving the treatment of periodontal furcation defects in nonhuman primates.

Related Experiment Videos

  • Administration of naturally derived and recombinantly produced human BMPs/OPs.
  • Analysis of periodontal tissue regeneration and morphogenesis.

    • Main Results:

    • BMPs/OPs effectively induced the formation of complex periodontal tissues in nonhuman primates with furcation defects.
    • Periodontal tissue regeneration occurred as a mosaic structure.
    • Osteogenic proteins (OPs) of the TGF-beta superfamily initiated and maintained tissue induction and morphogenesis, acting singly, synergistically, and synchronously.

    Conclusions:

    • BMPs/OPs are potent inducers of periodontal tissue regeneration, recapitulating embryonic development.
    • The application of BMPs/OPs shows promise for regenerating functionally oriented periodontal ligament fibers and cementum.
    • TGF-beta superfamily OPs play a critical role in orchestrating the complex process of periodontal tissue morphogenesis.