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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
Published on: March 13, 2013
Cell adhesion protein expression in melanocytic matricoma.
Alejandro Peralta Soler1, James L Burchette, Jane S Bellet
1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. alexpsoler@hotmail.com
Journal of Cutaneous Pathology
|May 24, 2007
Summary
This study investigated cadherin and beta-catenin expression in melanocytic matricoma, a rare skin neoplasm. Findings suggest the tumor resembles the anagen hair bulb, with beta-catenin potentially playing a transcriptional role.
Area of Science:
- Dermatopathology
- Molecular Biology
- Oncology
Background:
- Melanocytic matricoma is a rare skin neoplasm.
- Its histogenesis is thought to involve recapitulation of the anagen hair follicle.
- Cadherins and catenins are critical in hair follicle development.
Observation:
- A pigmented nodule on a 66-year-old woman's shoulder was diagnosed as melanocytic matricoma.
- Histopathology revealed basaloid, intermediate, and shadow cells with S-100 and HMB45-positive melanocytes.
- Immunohistochemistry examined E-, P-, and N-cadherin, and beta-catenin expression.
Findings:
- E-cadherin and P-cadherin were expressed at the cell membrane of basaloid cells, differentiating keratinocytes, and melanocytes, mimicking anagen hair.
- Both E- and P-cadherin were absent in shadow cells.
- Beta-catenin showed differential localization: nuclear/cytoplasmic in basaloid cells and membranous in differentiating cells, absent in shadow cells.
Implications:
- Results support the hypothesis that melanocytic matricoma resembles the anagen hair bulb.
- The differential expression of cadherins and beta-catenin provides insights into the tumor's development.
- Beta-catenin may have a transcriptional role in the pathogenesis of this rare neoplasm.
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