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Published on: December 19, 2020
Clinical features in secondary and cryptogenic organising pneumonia
O A Sveinsson1, H J Isaksson, A Sigvaldason
1Department of Respiratory Medicine, Sleep and Allergy, Landspitali University Hospital, Reykjavik, Iceland.
Summary
Clinical differences between cryptogenic organizing pneumonia (COP) and secondary organizing pneumonia (OP) were studied. Crackles were more common in secondary OP, but other clinical features were similar.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Pathology
Background:
- Clinical distinctions between cryptogenic organizing pneumonia (COP) and secondary organizing pneumonia (OP) require further investigation.
- Organizing pneumonia is a clinicopathological pattern seen in various lung diseases.
Purpose of the Study:
- To compare the clinical features of cryptogenic organizing pneumonia (COP) and secondary organizing pneumonia (OP).
Main Methods:
- A retrospective analysis of 104 patients diagnosed with organizing pneumonia was conducted.
- Data collected included causes, clinical presentation, treatment, radiographic findings, and pathology.
- Diagnostic methods included transbronchial biopsy, spirometry, and arterial blood gas analysis.
Main Results:
- Of 104 patients, 58 had COP and 46 had secondary OP. The average age was 68, and most patients were smokers.
- Infections were the most frequent cause of secondary OP. Cough was the most common symptom, and crackles were the most common sign.
- Crackles were significantly more prevalent in secondary OP (P=0.02). Spirometry and radiographic findings showed no significant differences between the groups. Treatment with corticosteroids was common, with similar relapse rates for both types.
Conclusions:
- There are no substantial clinical differences between cryptogenic organizing pneumonia (COP) and secondary organizing pneumonia (OP).
- The presence of crackles on auscultation may suggest secondary organizing pneumonia over cryptogenic organizing pneumonia.
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