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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000
C-S Yee1, D A Isenberg, A Prabu
1Department of Rheumatology, Division of Immunity and Infection, The Medical School (East Wing), University of Birmingham, Birmingham B15 2TT, UK. csyee@blueyonder.co.uk
Annals of the Rheumatic Diseases
|May 24, 2007
Summary
The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 is reliable for assessing lupus activity. However, the British Isles Lupus Assessment Group (BILAG)-2004 index is better at detecting active disease needing treatment adjustments.
Area of Science:
- Rheumatology
- Clinical Immunology
- Systemic Lupus Erythematosus Research
Background:
- Systemic Lupus Erythematosus (SLE) requires accurate disease activity assessment for effective management.
- Existing indices like SLEDAI-2000 and BILAG-2004 are used, but their comparative performance in routine practice needs evaluation.
Purpose of the Study:
- To evaluate the reliability of the SLEDAI-2000 index in routine clinical practice.
- To compare the ability of SLEDAI-2000 and BILAG-2004 to detect active SLE requiring treatment escalation.
Main Methods:
- Multi-center study involving 93 SLE patients assessed by two independent raters.
- Disease activity evaluated using both SLEDAI-2000 and BILAG-2004 indices.
- Reliability assessed by inter-rater agreement; detection of active disease compared against treatment changes.
Main Results:
- SLEDAI-2000 showed good item-level agreement (81.7-100%) but inter-rater score differences occurred in 46.2% of patients.
- BILAG-2004 identified more patients with high disease activity (37.6%) who had low SLEDAI-2000 scores and required increased treatment.
- Only 5.4% of patients showed low BILAG-2004 activity with high SLEDAI-2000 scores.
Conclusions:
- SLEDAI-2000 demonstrates reliability in assessing SLE disease activity in routine settings.
- BILAG-2004 is more sensitive than SLEDAI-2000 in identifying active SLE that warrants intensified treatment.
