Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metoclopramide does not decrease the incidence of nausea and vomiting after alfentanil for outpatient anaesthesia.

D G Whalley1, S AlHaddad, I Khalil

  • 1Department of General Anesthesiology, Cleveland Clinic Foundation, Ohio 44195.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre- and post-cranioplasty hydrocephalus in patients following decompressive craniectomy for ischemic stroke: a systematic review and meta-analysis.

Neurosurgical review·2025
Same author

The Impact of Inoculation of Two Strains of Rhizobacteria on Radionuclide Transfer in Sesbania Grandiflora.

Bulletin of environmental contamination and toxicology·2024
Same author

Prevention and screening during the COVID-19 pandemic: qualitative findings from the BETTER WISE project.

BMC primary care·2023
Same author

D-Dimer May be a Prognostic Hematological Marker for COVID-19: A Retrospective Case Analysis.

Mymensingh medical journal : MMJ·2021
Same author

Sub-continental Atmosphere and Inherent Immune System may have Impact on Novel Corona Virus' 2019 (nCovid-19) Prevalence in South East Asia.

Mymensingh medical journal : MMJ·2020
Same author

The importance of the patient voice in vaccination and vaccine safety-are we listening?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016

Adding metoclopramide to droperidol did not reduce nausea, retching, or vomiting in outpatients receiving alfentanil anesthesia for nasal surgery. The combination therapy showed no significant difference in emetic symptom incidence compared to droperidol alone.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Surgical Care

Background:

  • Postoperative nausea and vomiting (PONV) are common complications in outpatient surgery.
  • Alfentanil anesthesia is associated with a risk of emetic symptoms.
  • Droperidol is an antiemetic agent, but its efficacy may be enhanced by other drugs.

Purpose of the Study:

  • To evaluate the efficacy of metoclopramide in combination with droperidol for preventing emetic symptoms.
  • To determine if adding metoclopramide to droperidol further reduces nausea, retching, and vomiting in outpatients undergoing nasal surgery with alfentanil anesthesia.

Main Methods:

  • A randomized, double-blind, placebo-controlled study involving 60 outpatients.
  • Patients received either metoclopramide or placebo, combined with droperidol and alfentanil anesthesia.

Related Experiment Videos

  • Emetic symptoms were assessed at 0-3, 3-6, and 6-24 hours post-surgery.

    • Main Results:

    • The overall incidence of emetic symptoms was 27% in both the metoclopramide (Group 1) and placebo (Group 2) groups.
    • No statistically significant difference in the incidence of nausea, retching, or vomiting was observed between the groups at any time interval.
    • Both groups received comparable doses of alfentanil anesthesia.

    Conclusions:

    • Metoclopramide, when added to droperidol, does not provide additional antiemetic benefit in outpatients receiving alfentanil anesthesia for nasal surgery.
    • Droperidol alone appears to be as effective as the combination of metoclopramide and droperidol in managing emetic symptoms in this patient population.