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Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
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Positive selection within the Schizophrenia-associated GABA(A) receptor beta(2) gene

Wing-Sze Lo1, Zhiwen Xu, Zhiliang Yu

  • 1Department of Biochemistry, Applied Genomics Laboratory and HKH Bioinformatics Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Plos One
|May 24, 2007
PubMed
Summary

Positive selection in the GABRB2 gene, linked to schizophrenia, favors specific alleles that alter GABA(A) receptor function. These recent evolutionary changes impact receptor sensitivity, particularly in individuals with schizophrenia.

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