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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Alzheimer's Disease: Treatment

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Related Experiment Video

Updated: Jul 14, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Cognitive estimation in mild Alzheimer's disease.

A Barabassy1, U Beinhoff, M W Riepe

  • 1Department of Psychiatry, Charité Medical University, Berlin, Germany.

Journal of Neural Transmission (Vienna, Austria : 1996)
|May 24, 2007
PubMed
Summary

Patients with mild Alzheimer's disease (AD) show impaired time and weight estimation. These cognitive deficits, even in early stages, suggest caution for activities like driving.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Everyday tasks often rely on estimation rather than precise knowledge.
  • Cognitive estimation abilities can be affected by neurodegenerative diseases.

Purpose of the Study:

  • To investigate modality-specific cognitive estimation in patients with mild Alzheimer's disease (AD).
  • To assess estimation of weight, size, number, and time in AD patients compared to healthy controls (HC).

Main Methods:

  • Experimental assessment of cognitive estimation tasks (weight, size, number, time).
  • Comparison between healthy controls (n=49) and mild Alzheimer's disease patients (n=42).
  • Correlation analysis with age, general intellectual ability, verbal fluency, and clock drawing tests.

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Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
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Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Related Experiment Videos

Last Updated: Jul 14, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Main Results:

  • Alzheimer's disease patients were impaired in estimating time and weight.
  • Estimation of number, size, and distance remained intact in AD patients.
  • Time estimation deficits correlated with verbal fluency and clock drawing scores in AD patients.

Conclusions:

  • Mild Alzheimer's disease impairs time and weight estimation, even in early stages.
  • Deficits in time estimation suggest temporo-parietal and potentially frontal lobe involvement.
  • Cognitive estimation impairments highlight the need for caution in AD patients, particularly for activities like driving.