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Related Experiment Videos

Maternal serum cortisol and prolactin variations during labor.

E Salamalekis1, E Pyrgiotis, I Phoca

  • 12nd Dept of Obstetrics and Gynecology, Athens University, Areteion Hospital, Greece.

Clinical and Experimental Obstetrics & Gynecology
|January 1, 1991
PubMed
Summary

Maternal serum cortisol and prolactin levels change significantly during labor. Cortisol rises and prolactin falls, indicating the body

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Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Clinical Biochemistry

Background:

  • Hormonal changes during pregnancy and labor are complex.
  • Cortisol and prolactin play crucial roles in physiological adaptations.
  • Understanding labor-related hormonal shifts is vital for maternal health.

Purpose of the Study:

  • To investigate maternal serum cortisol and prolactin levels during labor.
  • To compare hormone levels based on labor onset and duration.
  • To correlate hormonal changes with the stress of labor.

Main Methods:

  • Maternal serum cortisol (F) and prolactin (PRL) were measured in 20 uncomplicated pregnancies.
  • Participants were grouped by membrane status (ruptured vs. intact), labor onset (spontaneous vs. induced), and labor duration (prolonged vs. normal).

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  • Hormone levels were analyzed before, during, and after labor.

    • Main Results:

    • Cortisol levels were higher before labor in women with ruptured membranes and spontaneous labor onset compared to intact membranes and induced labor, respectively.
    • During labor, a significant rise in cortisol and a significant fall in prolactin were observed in all women.
    • These hormonal changes were more pronounced in prolonged labor, with cortisol elevation and prolactin drop being more significant.

    Conclusions:

    • Labor-induced stress significantly impacts maternal cortisol and prolactin levels.
    • Elevated cortisol and decreased prolactin during labor may reflect physiological responses to physical and emotional stress.
    • Hormonal patterns differ based on labor characteristics, suggesting distinct adaptive mechanisms.