Related Experiment Video
Updated: Jul 14, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Prognostic significance of CD100 expression in soft tissue sarcoma
Eweseng Ch'ng1, Yasuhiko Tomita, Binglin Zhang
1Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Cancer
|May 24, 2007
Summary
CD100 expression in soft tissue sarcoma (STS) is linked to aggressive tumor features and poorer survival outcomes. Higher CD100 levels indicate a significant prognostic factor for both overall and disease-free survival in STS patients.
Area of Science:
- Oncology
- Cancer Biology
- Molecular Pathology
Background:
- CD100, a class IV semaphorin, is known to promote key cancer cell behaviors like angiogenesis and proliferation.
- Its role in soft tissue sarcoma (STS) and prognostic value remained to be fully elucidated.
Purpose of the Study:
- To evaluate the expression of CD100 in soft tissue sarcoma (STS).
- To determine the correlation between CD100 expression and clinicopathologic factors.
- To assess the prognostic significance of CD100 in STS patients.
Main Methods:
- Immunohistochemical analysis of CD100 expression on 81 localized STS patient samples.
- Categorization of CD100 staining intensity into three levels (1, 2, and 3).
- Parallel assessment of Ki-67 labeling index and correlation with clinicopathologic features and survival data.
Main Results:
- Over half of STS tumors (52%) exhibited lower CD100 expression (level 1).
- Higher CD100 expression levels (2 and 3) correlated with increased mitotic count, cellularity, necrosis, and Ki-67 index.
- Elevated CD100 expression was significantly associated with poorer overall and disease-free survival, identified as an independent prognosticator.
Conclusions:
- CD100 expression demonstrates significant prognostic value in soft tissue sarcoma.
- Higher CD100 levels are indicative of a more aggressive tumor phenotype and worse patient outcomes.
Related Concept Videos
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...