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Escaping the mouse trap: the selection of new Evo-Devo model species
Michel C Milinkovitch1, Athanasia Tzika
1Laboratory of Evolutionary Genetics, Institute for Molecular Biology & Medicine, Université Libre de Bruxelles, Gosselies, Belgium. mcmilink@ulb.ac.be
Summary
Choosing model species for research is shifting from human biology relevance to understanding biological diversity through evolutionary developmental (Evo-Devo) studies. A pragmatic approach and virtual zoos are proposed to advance Evo-Devo research.
Area of Science:
- Evolutionary developmental biology (Evo-Devo)
- Comparative genomics
- Model organism research
Background:
- Historically, model species selection prioritized relevance to human biology for medical research.
- Recent shifts favor understanding biological diversity through evolutionary developmental (Evo-Devo) mechanisms.
- Current criteria for model species are debated, impacting research direction.
Purpose of the Study:
- To discuss criteria and limitations for selecting model species in Evo-Devo research.
- To advocate for a more active role of the Evo-Devo community in defining model species.
- To propose solutions for overcoming challenges in Evo-Devo model species manipulation and breeding.
Main Methods:
- Literature review and discussion of criteria for model species selection.
- Analysis of the shift from medicine-driven to Evo-Devo-driven model species.
- Conceptual proposal for Evo-Devo virtual zoos and ordered embryo services.
Main Results:
- The criteria for model species are evolving, with a growing emphasis on Evo-Devo.
- A consensual list of Evo-Devo model species is lacking, hindering research integration.
- Innovative approaches like virtual zoos could facilitate Evo-Devo research.
Conclusions:
- A pragmatic approach is needed for selecting Evo-Devo model species.
- The Evo-Devo community must actively engage in defining suitable model organisms.
- Establishing Evo-Devo virtual zoos could significantly advance the field by providing accessible biological material.
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