Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung metastatic load limitation with hyperbaric oxygen.

Abu T M Y Haroon1, M Patel, A B Al-Mehdi

  • 1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|May 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selectable marker-free transgenic barley producing a high level of cellulase (1,4-beta-glucanase) in developing grains.

Plant cell reports·2003
Same author

Iridium-192 implantation for T1 and T2a carcinoma of the tongue and floor of mouth: retrospective study of the results of treatment at the Royal Berkshire Hospital.

The British journal of radiology·2003
Same author

Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis.

Oral microbiology and immunology·2003
Same author

Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors.

Molecular therapy : the journal of the American Society of Gene Therapy·2003
Same author

Age dependence of seizure-induced oxidative stress.

Neuroscience·2003
Same author

The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.

Journal of medical genetics·2003

Hyperbaric oxygen (HBO2) therapy did not enhance breast cancer metastasis in mice. Instead, HBO2 treatment significantly reduced large tumor colony size and number, suggesting it may restrict cancer growth.

Area of Science:

  • Oncology
  • Hyperbaric Medicine
  • Cancer Metastasis Research

Background:

  • Hyperbaric oxygen (HBO2) therapy is sometimes used in cancer patients despite theoretical concerns about promoting tumor growth.
  • The potential impact of HBO2 on cancer metastasis requires thorough investigation.

Purpose of the Study:

  • To evaluate the effect of hyperbaric oxygen (HBO2) therapy on the growth and metastasis of murine breast cancer cells in a lung experimental metastasis assay.

Main Methods:

  • Murine breast cancer cells (4T1-GFP) were injected intravenously into young nu/nu mice.
  • One group received daily hyperbaric oxygen (HBO2) treatment (2.8 ATA for 45 min, 5 days/week) for a specified period.
  • Tumor cell colonies in the lungs were quantified using epifluorescence microscopy at various time points post-injection.

Related Experiment Videos

Main Results:

  • Hyperbaric oxygen (HBO2) treatment did not increase the number of large or small tumor colonies in the lungs.
  • A significant reduction in the number of large colonies was observed at 1 and 16-21 days post-treatment.
  • Most importantly, a significant decrease in the size of large tumor colonies was consistently observed in the HBO2-treated group.

Conclusions:

  • Hyperbaric oxygen (HBO2) therapy does not appear to be prometastatic for breast cancer cells.
  • The findings suggest that HBO2 therapy may actually inhibit the growth of large tumor cell colonies.