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Lung metastatic load limitation with hyperbaric oxygen.

Abu T M Y Haroon1, M Patel, A B Al-Mehdi

  • 1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|May 25, 2007
PubMed
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Hyperbaric oxygen (HBO2) therapy did not enhance breast cancer metastasis in mice. Instead, HBO2 treatment significantly reduced large tumor colony size and number, suggesting it may restrict cancer growth.

Area of Science:

  • Oncology
  • Hyperbaric Medicine
  • Cancer Metastasis Research

Background:

  • Hyperbaric oxygen (HBO2) therapy is sometimes used in cancer patients despite theoretical concerns about promoting tumor growth.
  • The potential impact of HBO2 on cancer metastasis requires thorough investigation.

Purpose of the Study:

  • To evaluate the effect of hyperbaric oxygen (HBO2) therapy on the growth and metastasis of murine breast cancer cells in a lung experimental metastasis assay.

Main Methods:

  • Murine breast cancer cells (4T1-GFP) were injected intravenously into young nu/nu mice.
  • One group received daily hyperbaric oxygen (HBO2) treatment (2.8 ATA for 45 min, 5 days/week) for a specified period.
  • Tumor cell colonies in the lungs were quantified using epifluorescence microscopy at various time points post-injection.

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Main Results:

  • Hyperbaric oxygen (HBO2) treatment did not increase the number of large or small tumor colonies in the lungs.
  • A significant reduction in the number of large colonies was observed at 1 and 16-21 days post-treatment.
  • Most importantly, a significant decrease in the size of large tumor colonies was consistently observed in the HBO2-treated group.

Conclusions:

  • Hyperbaric oxygen (HBO2) therapy does not appear to be prometastatic for breast cancer cells.
  • The findings suggest that HBO2 therapy may actually inhibit the growth of large tumor cell colonies.