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Updated: Jul 14, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Pediatric and adolescent HIV disease.
Elizabeth Secord1, Cristina Cotronei-Cascardo
1CHM-Allergy/Immunology Division, Wayne State University, Detroit, Michigan 48201, USA. esecord@med.wayne.edu
Summary
Pediatric and adolescent human immunodeficiency virus (HIV) management has advanced significantly, with new treatments making HIV a manageable chronic condition and drastically reducing mother-to-child transmission rates.
Area of Science:
- Pediatric infectious diseases
- HIV/AIDS management
- Public health advancements
Background:
- Review of current literature and guidelines for pediatric and adolescent HIV diagnosis and treatment.
- Utilizes MEDLINE and CDC resources for comprehensive data.
- Incorporates expert opinions to create illustrative case studies.
Observation:
- Significant progress in pediatric and adolescent HIV prevention, diagnosis, and treatment over the last decade.
- HIV is now a manageable chronic illness with available antiretroviral therapies.
- Antiretroviral agents have dramatically reduced mother-to-child HIV transmission in industrialized nations to approximately 1%.
Findings:
- Reduced pill burden for children and adults with HIV, from multiple daily doses to once-daily regimens.
- Shift in HIV care focus from opportunistic infections to adherence, drug resistance, and adverse effect monitoring.
- Advances in antiretroviral therapy have transformed HIV into a manageable chronic condition.
Implications:
- The field of HIV diagnosis and treatment is dynamic, with evolving guidelines.
- Future advancements may include global access to current technologies and progress toward HIV prevention and cure.
- Continued research and guideline updates are crucial for optimal pediatric and adolescent HIV care.
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