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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Cross-reactivity

Cross-reactivity

Adrenergic Agonists: Therapeutic Uses

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...

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Related Experiment Video

Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Sea urchin roe (uni) anaphylaxis.

Robert W Hickey¹

¹Allergy Associates of NH, Portsmouth, New Hampshire 03801, USA. bobhickey@comcast.net

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|May 25, 2007

Summary

This study identifies sea urchin roe as a novel food allergen, detailing the first reported case of anaphylaxis caused by its consumption. This finding is crucial for diagnosing unexplained food allergies.

Area of Science:

Food allergy research
Immunology
Clinical diagnostics

Background:

Sea urchin roe (uni) is a delicacy in Japanese and Korean cuisine.
Previously, sea urchin roe has not been recognized as a potential food allergen.
Anaphylaxis is a severe, potentially life-threatening allergic reaction.

Observation:

A patient experienced anaphylaxis after consuming a sushi meal.
The meal included various seafood items such as shrimp, snow crab, sea urchin roe, and eel.
Diagnostic procedures included skin prick testing and serum IgE testing.

Findings:

Skin testing and IgE assays ruled out allergies to common seafood like shrimp, crab, and eel.
Positive skin prick test results were observed for fresh sea urchin roe.

More Related Videos

High Throughput Microinjections of Sea Urchin Zygotes

High Throughput Microinjections of Sea Urchin Zygotes

Published on: January 21, 2014

Related Experiment Videos

Last Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

High Throughput Microinjections of Sea Urchin Zygotes

High Throughput Microinjections of Sea Urchin Zygotes

Published on: January 21, 2014

This indicates specific IgE-mediated sensitization to sea urchin roe.

Implications:

This case is the first documented instance of anaphylaxis attributed to sea urchin roe.
It highlights the importance of considering uncommon foods as potential allergens.
Investigating novel food allergens can help diagnose unexplained cases of food-related anaphylaxis.