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Related Experiment Video

Updated: Jul 14, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

Immune system changes during simulated planetary exploration on Devon Island, high arctic.

Brian Crucian¹, Pascal Lee, Raymond Stowe

¹Wyle Laboratories/NASA-JSC, Houston, Texas 77058, USA. bcrucian@ems.jsc.nasa.gov

|May 25, 2007

Summary

Astronauts experience immune system changes similar to those seen in Arctic field teams. This study developed field-compatible methods for immune assessment, crucial for space exploration and remote terrestrial applications.

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Last Updated: Jul 14, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

Area of Science:

Human physiology
Space medicine
Immunology

Background:

Spaceflight dysregulates the immune system, posing risks for long missions.
Field-compatible clinical immunology techniques are needed for remote assessments.
NASA studied immune responses in Arctic field teams to simulate spaceflight stressors.

Purpose of the Study:

To evaluate the effect of mission-associated stressors on the human immune system.
To develop and test field-compatible techniques for immune sample processing.
To assess immune changes in participants of the Haughton-Mars Project (HMP).

Main Methods:

Developed a field protocol for immune sample collection and processing at a remote Arctic location.
Collected blood samples for immunophenotype analysis, functional assessments, and stress hormone levels.
Performed assays including leukocyte distribution, T cell activation, cytokine profiles, cortisol, and EBV antibody levels.

Main Results:

The developed field protocol for immune sample processing was successful.
Field participants showed distinct immune, phenotype, and stress hormone changes compared to baseline and recovery.
Observed immune changes mirrored those previously seen in astronauts after spaceflight.

Conclusions:

The Haughton-Mars Project serves as a valid analog for studying spaceflight-induced physiological changes.
The developed field protocol has potential applications for remote terrestrial immunology studies.
Elements of the protocol may be adaptable for in-flight immunology studies during space missions.