Related Experiment Video
Updated: Jul 14, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Atrial fibrillation and congestive heart failure: a two-way street
Nazem Akoum1, Mohamed H Hamdan
1University of Utah, 30 North 1400 East, Room 4A100, Salt Lake City, UT 84132, USA.
Insights
Atrial fibrillation (AF) in heart failure patients increases mortality. Rhythm control via drugs or ablation may improve symptoms and survival, but pacing effects need further study.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Heart Failure Management
Background:
- Atrial fibrillation (AF) is the most common arrhythmia in heart failure (HF).
- AF prevalence correlates with left ventricular dysfunction and HF severity.
- AF in HF patients is linked to increased mortality.
Purpose of the Study:
- To review mechanisms linking AF and HF morbidity/mortality.
- To discuss current treatment options for AF in HF.
- To evaluate the roles of radiofrequency ablation and pacing in AF and HF.
Main Methods:
- Literature review of proposed mechanisms.
- Analysis of studies on rhythm control therapies (drug therapy, catheter ablation).
- Discussion of potential benefits of AV junction ablation and biventricular pacing.
Main Results:
- Rhythm control (antiarrhythmic drugs, catheter ablation) shows symptomatic and survival benefits in HF with AF.
- The impact of AV junction ablation and biventricular pacing in permanent AF with HF requires further investigation.
Conclusions:
- AF significantly worsens outcomes in heart failure patients.
- Rhythm control strategies are crucial for managing AF in HF.
- Further research is needed on advanced pacing techniques for AF in HF.
Abstract:
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical cardiology, particularly in patients with heart failure. Its prevalence increases with the degree of left ventricular dysfunction and severity of heart failure symptoms. The development of AF in the setting of heart failure has been shown to result in increased mortality. Studies thus far indicate that rhythm control with antiarrhythmic drug therapy or catheter ablation offers both symptomatic and probably survival advantage in patients with heart failure and AF. In patients with permanent AF, the effects of restoring a regular ventricular response with atrioventricular junction ablation followed by biventricular pacing remain to be shown. In the current manuscript, we will review the proposed mechanisms of increased morbidity and mortality associated with AF and the current treatment options including the roles of radiofrequency ablation and pacing.
Related Concept Videos
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Cardiomyopathy II: Dilated Cardiomyopathy
Heart Failure I: Introduction
Heart Failure IV: Classification and Diagnostic Evaluation
