Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NRG1 and synaptic function in the CNS.

Gerald D Fischbach1

  • 1Columbia University, New York, NY 10027, USA. gf224@columbia.edu

Neuron
|May 25, 2007
PubMed
Summary
This summary is machine-generated.

Neuregulin 1 (NRG1) and its receptor erbB4 are implicated in schizophrenia. New research shows they regulate synaptic transmission in the brain, suggesting potential synaptic defects in the disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder?

Autism : the international journal of research and practice·2015
Same author

The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2013
Same author

Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex.

Proceedings of the National Academy of Sciences of the United States of America·2011
Same author

The Simons Simplex Collection: a resource for identification of autism genetic risk factors.

Neuron·2010
Same author

Neuroethicists needed now more than ever.

The American journal of bioethics : AJOB·2008
Same author

An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2006
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Genetic studies suggest Neuregulin 1 (NRG1) and its receptor erbB4 are linked to schizophrenia susceptibility.
  • The precise roles of NRG1 and erbB4 in central nervous system (CNS) synaptic transmission and circuitry remain unclear.

Discussion:

  • Recent studies demonstrate that NRG1 and erbB4 play a regulatory role in synaptic transmission.
  • These findings specifically highlight the involvement of NRG1 and erbB4 at both glutamate and GABA synapses in the brain.

Key Insights:

  • NRG1 and erbB4 modulate excitatory (glutamate) and inhibitory (GABA) neurotransmission in the brain.
  • This regulation of synaptic function by NRG1 and erbB4 is a novel finding with implications for understanding brain circuitry.

Related Experiment Videos

Outlook:

  • The identified roles of NRG1 and erbB4 in synaptic transmission open new avenues for investigating the pathophysiology of schizophrenia.
  • These discoveries suggest that synaptic defects could be a contributing factor to schizophrenia development.