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Related Experiment Videos

Surfing on calcium waves.

Janet Alder1, James Q Zheng

  • 1Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. alderja@umdnj.edu

Neuron
|May 25, 2007
PubMed
Summary
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Neuronal migration in brain development is guided by repulsive Slit molecules. Cerebellar granule neurons sense these signals, triggering a calcium wave that reverses cell polarity and directs migration.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neuronal migration is crucial for establishing the layered structure of the brain.
  • Understanding the guidance mechanisms for neuronal precursors is a key question in brain development.

Purpose of the Study:

  • To investigate how migrating cerebellar granule neurons are guided during brain development.
  • To elucidate the molecular mechanisms underlying neuronal migration and polarity reversal.

Main Methods:

  • The study utilized migrating cerebellar granule neurons.
  • Investigated the role of Slit molecules and calcium signaling in neuronal migration.

Main Results:

  • The leading process of migrating neurons senses repulsive Slit molecules.

Related Experiment Videos

  • This sensing generates a calcium (Ca2+) wave that propagates to the cell body (soma).
  • The calcium wave induces reversal of cell polarity, controlling migration direction.

    • Conclusions:

    • Slit molecules act as repulsive cues guiding neuronal migration.
    • Calcium waves play a critical role in mediating the response to guidance cues.
    • This mechanism explains how neuronal precursors establish ordered laminar layers in the brain.