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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models

Joy L Kovar1, Melanie A Simpson, Amy Schutz-Geschwender

  • 1LI-COR Biosciences, Lincoln, NE 68504, USA.

Analytical Biochemistry
|May 25, 2007
PubMed
Abstract

No abstract available in PubMed .

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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