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Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
Yuki Kawakubo1, Satoru Kamio, Takahiko Nose
1Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yukik-tky@umin.ac.jp
Abstract:
Neurobiological mechanisms for social skills acquisition in schizophrenia remain largely unknown. We investigated whether an electrophysiological index of cognitive function predicts the degree of training-related social skills improvement in schizophrenia. Thirteen patients with schizophrenia underwent assessment of mismatch negativity (MMN) event-related potentials, followed by participation in a 3-month social skills training. Larger right frontal/temporal MMN current density values elicited by across-phoneme change were significantly associated with individual degrees of improvement in total social skills scores as assessed by a structured role play test. Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia.
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