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Improving surveillance for antimalarial drug resistance

Jean-Paul Chretien1, Mark Fukuda, Harald Noedl

  • 1US Department of Defense Global Emerging Infections Surveillance & Response System, Silver Spring, Md 20910, USA. jean-paul.chretien@na.amedd.army.mil

JAMA
|May 25, 2007
PubMed
Summary

No abstract available in PubMed .

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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