Related Experiment Video
Updated: Jul 14, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?
1Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands. a.roos@lumc.nl
Abstract:
Moldoveanu et al. present a diagnostic test for IgA nephropathy based on the presence of undergalactosylated IgA in serum. This underglycosylated IgA appears to be overrepresented in serum of IgA nephropathy patients and is most likely related to mesangial IgA deposition. Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease.
More Related Videos
Related Concept Videos
Diabetic Nephropathy
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Proteoglycans
Hyperglycemia
Type I Diabetes III: Clinical Manifestations
Type I Diabetes I: Introduction

