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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Published on: March 26, 2018

Bilateral orbital myeloid sarcoma as initial manifestation of acute myeloid leukemia

Kamel Hmidi1, Sonia Zaouali, Riadh Messaoud

  • 1Department of Ophthalmology, Tahar Sfar University Hospital, Mahdia, Tunisia.

International Ophthalmology
|May 25, 2007
PubMed

Insights

Orbital granulocytic sarcoma, a rare complication of acute myeloid leukemia (AML), can present as bilateral proptosis in children. Prompt diagnosis and chemotherapy with steroids led to complete remission in a pediatric case.

Area of Science:

  • Oncology
  • Ophthalmology
  • Hematology

Background:

  • Granulocytic sarcoma is a rare orbital complication of acute leukemia, primarily affecting children under 10 with acute myeloid leukemia.
  • Diagnosis involves clinical examination, CT scans, and hematological investigations.
  • Treatment combines chemotherapy and intravenous steroid therapy.

Observation:

  • A 6-year-old girl presented with bilateral proptosis, indicative of acute myeloid leukemia.
  • The patient received a two-phase chemotherapy regimen combined with intravenous steroids.

Findings:

  • The treatment resulted in complete remission after a 24-month follow-up period.
  • This case highlights the successful management of orbital granulocytic sarcoma in a pediatric patient.

Implications:

  • Orbital masses of uncertain origin, especially bilateral ones, warrant consideration for granulocytic sarcoma.
  • Special stains and immunohistochemistry are crucial for accurate diagnosis of granulocytic sarcoma.
Abstract

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