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Updated: Jul 14, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Successful intravenous thrombolysis in ischemic stroke caused by infective endocarditis
Mithri Junna1, Chang-Ching D Lin, Raul E Espinosa
1Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Mayo W8B, Rochester, MN 55905, USA.
Introduction:
Infective endocarditis can lead to serious neurological complications including ischemic stroke and intracranial hemorrhage. Treatment with intravenous thrombolysis within 3 h of symptom onset has become the standard of care in acute ischemic stroke, but the safety and efficacy of this intervention in patients with infective endocarditis is unknown.
Summary Of Case:
We report the case of a patient with ischemic stroke who experienced substantial neurological improvement after being treated with intravenous thrombolysis (NIH stroke scale score of 15 on admission and 4 after treatment) and was subsequently found to have acute infective mitral endocarditis.
Conclusion:
Favorable response to thrombolysis may occur in patients with stroke due to infectious endocarditis. The safety of this therapy remains to be established.
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