Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cytokines].

M Feuchtenberger1, C Kneitz, H-P Tony

  • 1Schwerpunkt Rheumatologie/Klinische Immunologie, Medizinische Klinik mit Poliklinik II der Universität Würzburg, Klinikstrasse 6, 97070 Würzburg. feuchtenbe_m@klinik.uni-wuerzburg.de

Zeitschrift Fur Rheumatologie
|May 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnosis and treatment of ANCA-associated vasculitis : S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for ENT Medicine and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
Same author

[Diagnosis and treatment of ANCA-associated vasculitis : SHORT VERSION of the S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for Otorhinolaryngology and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
Same author

[Corona vaccination under immunosuppression].

Zeitschrift fur Rheumatologie·2024
Same author

[Influence of underlying disease and immunosuppression on the immunocompetence in inflammatory rheumatic diseases].

Zeitschrift fur Rheumatologie·2023
Same author

[Further development of regional early care-Many roads lead to Rome : Developmental stages of four established rheumatological early care concepts in different regions of Germany].

Zeitschrift fur Rheumatologie·2022
Same author

Joint Statement (DZK, DGRh, DDG) on the Tuberculosis Risk with Treatment Using Novel Non-TNF-Alpha Biologicals.

Pneumologie (Stuttgart, Germany)·2021
Same journal

[Prevention strategies in rheumatoid arthritis : From primary prevention to targeted drug interception].

Zeitschrift fur Rheumatologie·2026
Same journal

Methodological concerns and data discrepancies in the indirect treatment comparison of belimumab and anifrolumab.

Zeitschrift fur Rheumatologie·2026
Same journal

Evaluating the comparative efficacy of belimumab vs. anifrolumab in systemic lupus erythematosus: a response.

Zeitschrift fur Rheumatologie·2026
Same journal

[Update: DMARDs for MGUS].

Zeitschrift fur Rheumatologie·2026
Same journal

[A potpourri of diagnoses-Unusual manifestations of a chronic inflammatory bowel disease : Case report].

Zeitschrift fur Rheumatologie·2026
Same journal

[Not measurable but immeasurably important : Fever-The leading symptom of ancient medical theory].

Zeitschrift fur Rheumatologie·2026
See all related articles

Cytokine-driven inflammation is central to autoimmune diseases. Inhibiting key cytokines like TNF-alpha and IL-1 offers significant clinical benefits, with future strategies targeting IL-6 and IL-15.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathophysiology

Context:

  • Cytokines are crucial for immune regulation, controlling infections and cancer via cell cycle and apoptosis.
  • Autoimmune diseases feature persistently elevated cytokine levels in inflamed tissues.
  • Understanding cytokine roles is vital for immune system research.

Purpose:

  • To explore the therapeutic potential of modulating cytokine activity in autoimmune diseases.
  • To highlight the success of inhibiting specific pro-inflammatory cytokines.
  • To identify future cytokine targets for improved treatment strategies.

Summary:

  • Cytokine-driven inflammation is a hallmark of autoimmune disorders.
  • Inhibiting tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) has proven effective in rheumatoid arthritis treatment.

Related Experiment Videos

  • Targeting additional cytokines like IL-6 and IL-15 presents promising future therapeutic avenues.

    • Impact:

    • Demonstrates the clinical efficacy of cytokine inhibition in autoimmune conditions.
    • Provides a rationale for developing novel immunomodulatory therapies.
    • Suggests a paradigm shift towards targeted cytokine-based treatments for autoimmune diseases.