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Updated: Jul 14, 2026

Protein Isolation from the Developing Embryonic Mouse Heart Valve Region
Published on: September 23, 2014
Bone formation in cardiac valves: a histopathological study of 128 cases
Ivo Steiner1, Petra Kasparová, Ales Kohout
1The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital, 500 05 Hradec Králové, Czech Republic. steiner@lfhk.cuni.cz
Abstract:
In a series of 1,177 patients with surgical valve resection, there were 128 (10.9%) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8%) than in women (8.5%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely.
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