Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Autoinflation compared to ventilation tubes for treating chronic otitis media with effusion.

Acta oto-laryngologica·2022
Same author

Incidental Thyroid cancer in patients undergoing surgery for hyperthyroidism.

American journal of otolaryngology·2019
Same author

CD4-positive lymphoepithelial-like carcinoma: Report of unusual case.

Avicenna journal of medicine·2018
Same author

Performance Characteristics of Adenoid Cystic Carcinoma of the Salivary Glands in Fine-Needle Aspirates.

Archives of pathology & laboratory medicine·2016
Same author

Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma.

BMC cancer·2014

Related Experiment Video

Updated: Jul 14, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
07:44

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

Mucosal secretion changes during radiotherapy in the oral cavity.

Luaay Aziz1, Anders Ebenfelt

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska University Hospital, 413 45, Göteborg, Sweden.

Clinical Oral Investigations
|May 25, 2007
PubMed
Summary

Oral mucositis, a painful side effect of head and neck cancer radiation therapy, may be linked to increased granulocytes in mucosal secretions. These cells, however, showed no signs of phagocytosis in patients who developed mucositis.

More Related Videos

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
09:10

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Published on: May 4, 2018

Related Experiment Videos

Last Updated: Jul 14, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
07:44

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
09:10

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Published on: May 4, 2018

Area of Science:

  • Oncology
  • Immunology
  • Oral Medicine

Background:

  • Oral mucositis is a debilitating complication of radiotherapy for head and neck cancer.
  • It causes significant pain, discomfort, and can necessitate treatment interruption or hospitalization.
  • The exact mechanisms driving mucositis development remain unclear.

Purpose of the Study:

  • To investigate the pathogenesis of oral mucositis during radiation therapy.
  • To analyze the cellular composition and function in mucosal secretions of patients undergoing radiotherapy.

Main Methods:

  • An imprint technique was used to collect mucosal secretions from ten head and neck cancer patients undergoing radiation therapy.
  • Cellular composition and function within the secretions were examined.

Main Results:

  • In eight out of ten patients, an increase in granulocytes was observed in mucosal secretions after two weeks of radiation therapy.
  • Despite increased numbers, these granulocytes did not exhibit phagocytic activity.
  • All ten patients developed oral mucositis.

Conclusions:

  • The study suggests a potential role for granulocytes in the pathogenesis of radiation-induced oral mucositis.
  • Elevated granulocyte levels in secretions, without phagocytosis, may contribute to mucositis development.