Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate stem cells and cancer.

A Y Nikitin1, A Matoso, P Roy-Burman

  • 1Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA. an58@cornell.edu

Histology and Histopathology
|May 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unidirectional ray polaritons in twisted asymmetric stacks.

Nature communications·2024
Same author

Twist-tunable polaritonic nanoresonators in a van der Waals crystal.

NPJ 2D materials and applications·2024
Same author

Multiple and spectrally robust photonic magic angles in reconfigurable α-MoO<sub>3</sub> trilayers.

Nature materials·2023
Same author

Hyperspectral Nanoimaging of van der Waals Polaritonic Crystals.

Nano letters·2021
Same author

Planar refraction and lensing of highly confined polaritons in anisotropic media.

Nature communications·2021
Same author

Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition.

Science advances·2021
Same journal

Morphological, molecular, and electrophysiological aspects of skeletal muscle satellite cell-niche interactions: Focus on interstitial stromal non-myogenic cells.

Histology and histopathology·2026
Same journal

Age-related morphological and histological changes in the dromedary camel thymus.

Histology and histopathology·2026
Same journal

Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

Histology and histopathology·2026
Same journal

FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

Histology and histopathology·2026
Same journal

Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

Histology and histopathology·2026
Same journal

Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway.

Histology and histopathology·2026
See all related articles

Cancer stem cells, possessing self-renewal properties, may drive prostate cancer development and metastasis. Understanding their biology is crucial for developing effective therapies against treatment-resistant prostate neoplasms.

Area of Science:

  • Oncology
  • Stem Cell Biology

Background:

  • Neoplastic cells and stem cells share properties, suggesting stem cells may be targets for malignant transformation.
  • Somatic stem cells or transit-amplifying cells with reacquired self-renewal capacity are implicated in cancer development.

Purpose of the Study:

  • To review the significance of the stem cell model in understanding prostate cancer pathogenesis.
  • To discuss animal studies relevant to the stem cell model of prostate cancer.
  • To explore the role of cancer stem cells in prostate cancer metastasis and treatment resistance.

Main Methods:

  • Literature review focusing on the stem cell model in prostate cancer.
  • Analysis of animal studies investigating cancer stem cell properties.
  • Discussion of therapeutic implications based on cancer stem cell biology.

Related Experiment Videos

Main Results:

  • Cancer stem cells, characterized by self-renewal, are proposed as key drivers of prostate cancer.
  • Dissemination of cancer stem cells may lead to metastatic disease.
  • Resistance of cancer stem cells to therapies like androgen ablation contributes to treatment failure.

Conclusions:

  • The stem cell model provides valuable insights into prostate cancer pathogenesis.
  • Targeting cancer stem cells is essential for developing effective therapies for prostate neoplasms.
  • Further research into cancer stem cell biology is needed to improve treatment outcomes.