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Hepatocellular adenoma with malignant alteration.

Radoje Colovic1, Nikica Grubor, Marjan Micev

  • 1Institute for Digestive Diseases, Clinical Center of Serbia, Belgrade, Serbia and Montenegro. marcolov@EUnet.yu

Hepato-Gastroenterology
|May 26, 2007
PubMed
Summary
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This case study highlights a rare malignant alteration in a hepatocellular adenoma. The patient, a 70-year-old woman with no history of hormone use, developed this liver tumor.

Area of Science:

  • Hepatology
  • Oncology
  • Pathology

Background:

  • Hepatocellular adenoma (HCA) is a rare benign liver tumor.
  • HCAs predominantly affect women using oral contraceptives.
  • Malignant transformation of HCA is exceptionally rare, with few documented cases.

Observation:

  • A 70-year-old woman, with no history of oral contraceptive or hormone use, presented with an incidentally discovered abdominal tumor.
  • Imaging (ultrasonography and CT scan) revealed a solitary, well-defined liver mass.
  • Surgical excision confirmed a large (115 x 100 x 90 mm) hepatocellular adenoma with malignant features.

Findings:

  • Histological examination confirmed hepatocellular adenoma with malignant alteration.
  • The patient represents the oldest reported case of malignant HCA.

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  • This case is notable for the absence of oral contraceptive or hormone use in the patient's history.

    • Implications:

    • This case expands the known clinical spectrum of hepatocellular adenoma, particularly regarding malignant transformation.
    • It underscores the importance of considering HCA in older individuals, even without typical risk factors.
    • Further research may be needed to understand non-hormonal pathways in HCA development and malignant progression.