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Prediction of lymph node metastasis by size of early gastric carcinoma
Eigo Otsuji1, Yoshiaki Kuriu, Daisuke Ichikawa
1Department of Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan. otsuji@koto.kpu-m.ac.jp
Background/Aims:
Tumor size requires more investigation as a factor in determining extent of regional lymph node dissection in early gastric carcinoma. We retrospectively investigated 573 patients with such tumors to identify predictors of lymph node metastasis.
Methodology:
Postoperative survival was examined for groups of patients defined by tumor size under 2 cm, between 2 and 4cm, and over than 4cm. Factors predicting tumor recurrence and regional lymph node metastasis also were determined.
Results:
Postoperative survival of patients with tumors larger than 4 cm was significantly worsethan that of patients with tumors smaller than 2 cm. Multivariate analysis identified lymph node metastasis as a significant risk factor for recurrence of early gastric carcinoma, while identifying primary tumor size and lymphatic vessel involvement as significant risk factors for lymph node metastasis.
Conclusions:
Lymph node metastasis, which increased risk of postoperative recurrence in early gastric carcinoma, was related to tumor size.
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