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Updated: Jul 14, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Alpha-1-antitrypsin deficiency asthma and allergy
A G Palma-Carlos1, M L Palma-Carlos
1Clinical Allergy Immunology Center-CAIC, Lisbon, Portugal.
Abstract:
The biochemistry, genetics and pathology of alpha-1-anti-trypsin deficiency are reviewed. The geographical distribution in Europe of more current phenotypes M, SZ is discussed. Two cases of alpha-1- anti-trypsin are presented one homozygotic ZZ non-smoker without any respiratory pathology and one heterozygotic SZ heavy smoker with a severe chronic obstructive pulmonary disease and reversibility to Beta-2-mimetics suggesting asthma. The relationship between alpha-1-antitrypsin and asthma is discussed and general measures of treatment or prevention suggested.
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