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Related Concept Videos

Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

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C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position
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The Medstone fixed, mobile, and modular configurations: impact on efficacy.

Adam Nicholson1, Courtney Lee, Roland Ugarte

  • 1Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota 55455-0392, USA.

Journal of Endourology
|May 26, 2007
PubMed
Summary

New configurations of the Medstone STS lithotripter, including mobile and operating-room units, show improved stone-free rates and efficiency compared to the original fixed machine. The modular operating-room unit (STS-T) demonstrated the highest efficiency quotient.

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Area of Science:

  • Urology
  • Medical Devices
  • Nephrology

Background:

  • Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for kidney stones.
  • The Medstone STS lithotripter has undergone several configuration changes.
  • Evaluating the efficacy of different lithotripter configurations is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To compare the efficacy of three Medstone STS lithotripter configurations: fixed-site (STS-FIX), mobile (STS-MOB), and operating-room (STS-T).
  • To assess stone-free rates, need for auxiliary procedures, re-treatment rates, and calculate an efficiency quotient (EQ) for each configuration.

Main Methods:

  • A retrospective analysis of 13,131 patients treated between 1999 and 2002.
  • Patients were treated with STS-FIX (52%), STS-MOB (26%), or STS-T (22%) units.
  • Follow-up included plain abdominal radiography to determine stone-free status and assess need for further interventions.

Main Results:

  • Overall stone-free rates were 59% (STS-FIX), 62% (STS-MOB), and 65% (STS-T).
  • The STS-FIX showed lower efficacy for lower-pole stones and larger stone sizes (21-30 mm) but higher efficacy for middle ureteral stones.
  • The STS-T achieved the highest overall efficiency quotient (59), followed by STS-MOB (56) and STS-FIX (50).

Conclusions:

  • New configurations of the STS lithotripter significantly improve efficacy over the original fixed unit.
  • The modular operating-room configuration (STS-T) offers the highest efficiency, potentially due to real-time fluoroscopy.
  • Configuration choice impacts treatment outcomes and efficiency in SWL procedures.