Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine in rheumatoid arthritis.

M Adlesic1, M Verdrengh, M Bokarewa

  • 1Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden.

Scandinavian Journal of Immunology
|May 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The architecture of the Gram-positive bacterial cell wall.

Nature·2020
Same author

Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort.

BMJ open·2019
Same author

Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in man.

Metabolism: clinical and experimental·2019
Same author

Should oral corticosteroids be prescribed for preschool viral wheeze? - Authors' reply.

The Lancet. Respiratory medicine·2018
Same author

Oral prednisolone in preschool children with virus-associated wheeze: a prospective, randomised, double-blind, placebo-controlled trial.

The Lancet. Respiratory medicine·2018
Same author

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Science immunology·2017
Same journal

Therapeutic Potential of Group 2 Innate Lymphoid Cells in Neuroinflammatory Diseases.

Scandinavian journal of immunology·2026
Same journal

Recent Thymic Emigrant Levels in Inborn Errors of Immunity: Is Their Diagnostic Value Greater Than We Think?

Scandinavian journal of immunology·2026
Same journal

The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript?

Scandinavian journal of immunology·2026
Same journal

Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4<sup>+</sup> T Cell Subsets in APECED.

Scandinavian journal of immunology·2026
Same journal

RETRACTION: Interleukin-13 Induces T Helper Type 2 Immune Responses in OVA-Immunized BALB/c Mice Bearing a T Cell Lymphoma.

Scandinavian journal of immunology·2026
Same journal

Development of a Detection Method for Soluble Urokinase-Type Plasminogen Activator Receptor and Its Application in Predicting Prognosis of Severe COVID-19.

Scandinavian journal of immunology·2026
See all related articles

Histamine levels are lower in rheumatoid arthritis (RA) patients

Area of Science:

  • Immunology
  • Rheumatology
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) is an autoimmune disease causing joint inflammation and erosion.
  • Synovial mast cells and histamine are implicated as key mediators in RA pathogenesis.
  • Understanding histamine's role is crucial for RA treatment strategies.

Purpose of the Study:

  • To quantify free histamine levels in serum and synovial fluid of RA patients.
  • To investigate the inflammatogenic potential of histamine in vitro and in vivo.
  • To assess histamine levels in RA patients receiving anti-TNF-alpha therapy.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) for histamine quantification in patient serum and synovial fluid.
  • Intra-articular histamine injection in murine knee joints to assess inflammation induction.

Related Experiment Videos

  • Analysis of histamine levels in RA patients undergoing anti-TNF-alpha treatment.

    • Main Results:

    • RA patients exhibited significantly lower serum histamine levels compared to healthy controls.
    • Synovial fluid histamine levels in RA patients were even lower than in serum.
    • Anti-TNF-alpha treatment correlated with increased circulating histamine levels in RA patients.
    • In vivo animal studies indicated histamine does not induce joint inflammation independently.

    Conclusions:

    • Histamine levels are reduced in rheumatoid arthritis patients, both systemically and locally.
    • Histamine does not appear to be a primary inflammatogenic agent in RA.
    • Further research may explore the complex role of histamine in RA pathogenesis and treatment response.