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Updated: Jul 14, 2026
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas
G Borzacchiello1, V Russo, M Russo
1Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Faculty of Veterinary Medicine, University of Naples Federico II Via F. Delpino, 1-80137 Naples, Italy. borzacch@unina.it
Abstract:
Ovarian tumours among domestic animals are frequently encountered in bitch. Cyclooxygenase-2 (COX-2) expression has been evaluated in different kind of canine primary epithelial neoplasms. Eleven canine ovarian carcinomas and two normal samples were evaluated immunohistochemically for COX-2 expression. Nine of 11 carcinoma samples (81%) expressed COX-2 enzyme isoform. The immunoreactivity was intracytoplasmically recorded and the intensity ranged from faint to strong. Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis.
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