Related Experiment Video

Updated: Jul 14, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

[A study on the hepatic histological changes and clinical manifestations in chronic HBV carriers]

Ni Wei1, Dong Yang, Fang Yang

  • 1Sixth People's Hospital of Shenyang, Shenyang 110006, China. weini2388@hotmail.com

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|May 26, 2007
PubMed

Insights

This study on chronic hepatitis B (HBV) carriers found mild liver inflammation and high HBV DNA replication. Liver inflammation grade correlates with fibrosis, but not HBV DNA levels or HBeAg status.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Context:

  • Chronic hepatitis B virus (HBV) infection affects millions globally.
  • Understanding the interplay between viral load, liver damage, and clinical markers is crucial for patient management.
  • Hepatic histopathological changes provide direct insights into disease progression.

Purpose:

  • To investigate the relationship between hepatic histopathological changes and clinical characteristics in chronic HBV carriers.
  • To assess correlations between HBV DNA replication, HBeAg status, and liver inflammation/fibrosis.
  • To explore the association of specific biochemical markers with liver pathology.

Summary:

  • A retrospective analysis of 142 chronic HBV carriers revealed high HBV DNA replication (average >10^4 copies/mL) and HBeAg positivity in most cases (95.3%).
  • Mild liver inflammation (G ≥ 1) was diagnosed in 106 cases, with one case showing early cirrhosis (G4S4).
  • Spearman's analysis showed a correlation between inflammation grade (G) and hepatic fibrosis index PCIII (r=0.391, P=0.003), with higher PCIII in carriers with inflammation compared to non-active carriers (P=0.016).

Impact:

  • Findings suggest that while inflammation grade correlates with fibrosis, it is independent of HBV DNA levels or HBeAg positivity in this cohort.
  • Elevated PCIII levels may indicate active hepatic inflammation in chronic HBV carriers.
  • This study contributes to understanding the histopathological landscape of chronic HBV and its clinical correlates.
Abstract

More Related Videos

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...