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[Liver pathology in idiopathic portal hypertension]
Xia Liu1, Tai-ling Wang, Can-hong Xiang
1Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China.
Objective:
To study the histopathological changes of livers in idiopathic portal hypertension (IPH).
Methods:
Liver specimens from 29 cases with idiopathic portal hypertension were studied. Histological preparations of the livers were stained with haematoxylin eosin and Masson's trichrome; reticular fibers in the liver tissues were demonstrated. The slides were also stained using some immunohistochemistry methods, and the pathological changes of the livers were analyzed.
Results:
The characteristic changes found in these IPH livers were dense portal fibrosis; obliteration, with or without phlebitis, of the branches of the portal vein; dilatation of the sinusoids; atrophy and nodular hyperplasia of liver cells.
Conclusions:
Histopathological changes of the livers in IPH are dense portal fibrosis, portal vein branch obliteration and nodular hyperplasia of liver cells. These are the main features for a histopathological diagnosis of IPH.
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