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Updated: Jul 14, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Trafficking motifs in the SARS-coronavirus nucleocapsid protein
Jae-Hwan You1, Mark L Reed, Julian A Hiscox
1Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Abstract:
The severe acute respiratory syndrome-coronavirus nucleocapsid (N) protein is involved in virus replication and modulation of cell processes. In this latter respect control may in part be achieved through the sub-cellular localisation of the protein. N protein predominately localises in the cytoplasm (the site of virus replication and assembly) but also in the nucleus/nucleolus. Using a combination of live-cell and confocal microscopy coupled to mutagenesis we identified a cryptic nucleolar localisation signal in the central part of the N protein. In addition, based on structural comparison to the avian coronavirus N protein, a nuclear export signal was identified in the C-terminal region of the protein.
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