Related Experiment Video
Updated: Jul 14, 2026
09:19
Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Appendiceal neoplasms and pseudomyxoma peritonei: a population based study
R M Smeenk1, M L F van Velthuysen, V J Verwaal
1Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. r.m.smeenk@amc.uva.nl
Summary
Pseudomyxoma peritonei (PMP) incidence is higher than previously thought, often originating from appendiceal mucinous neoplasms. These appendiceal lesions, particularly mucinous types, significantly increase the risk of developing PMP.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Pseudomyxoma peritonei (PMP) is a rare malignancy.
- Its origin is typically linked to appendiceal mucinous epithelial neoplasms.
- The exact incidence of appendiceal neoplasms progressing to PMP is not well-established.
Purpose of the Study:
- To determine the incidence of primary epithelial appendiceal lesions.
- To investigate the relationship between these lesions and the development of PMP.
- To assess the incidence of PMP in the Netherlands.
Main Methods:
- Utilized the nationwide pathology database of the Netherlands (PALGA) from 1995-2005.
- Analyzed data on appendectomies, primary epithelial appendiceal lesions, and PMP patient histories.
- Cross-referenced PMP cases with appendiceal pathology records.
Main Results:
- Appendiceal lesions were found in 0.9% of 167,744 appendectomies.
- 9% of patients with appendiceal lesions developed PMP.
- Mucinous epithelial appendiceal neoplasms showed a 20% progression rate to PMP, while other types had lower rates (2-3%).
- The incidence of PMP in the Netherlands was found to be nearly 2 per million per year.
- The appendix was the primary site in 82% of identified PMP cases.
Conclusions:
- Primary epithelial appendiceal lesions are uncommon.
- Mucinous epithelial neoplasms of the appendix are a significant precursor to PMP.
- The incidence of PMP may be underestimated.
- Patients with appendiceal epithelial neoplasms have a notable risk of concurrent colonic neoplasms.
More Related Videos
Related Concept Videos
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
01:22Appendicitis-I: Introduction
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
01:25Assessment of the Rectum and Anus
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...