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Updated: Jul 14, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Neurotrophins and schizophrenia
Peter F Buckley1, Sahebarao Mahadik, Anilkumar Pillai
1Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States. pbuckley@mail.mcg.edu
Abstract:
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
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