Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small intestinal length: a factor essential for gut adaptation.

L T Weaver1, S Austin, T J Cole

  • 1MRC Dunn Nutrition Unit, Cambridge.

Gut
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Viral metagenomics reveals the presence of novel Zika virus variants in Aedes mosquitoes from Barbados.

Parasites & vectors·2021
Same author

Bronchiolitis obliterans as a long-term sequela of Stevens-Johnson syndrome and toxic epidermal necrolysis in children.

Clinical and experimental dermatology·2019
Same author

Complications of augmentation procedures for dental implants in private practice, Victoria, Australia.

Australian dental journal·2019
Same author

Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes.

Obstetric medicine·2016
Same author

Experience of a new high-purity factor X concentrate in subjects with hereditary factor X deficiency undergoing surgery.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Successful combined liver/kidney transplantation from a donor with Pompe disease.

Molecular genetics and metabolism·2015
Same journal

USP20 promotes CD8<sup>+</sup> T cell exhaustion and impairs KRAS<sup>G12D</sup> inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer.

Gut·2026
Same journal

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease.

Gut·2026
Same journal

<i>Helicobacter pylori</i> infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.

Gut·2026
Same journal

Correction: Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Gut·2026
Same journal

Correction: Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.

Gut·2026
Same journal

Cancer risk in autoimmune gastritis: perspectives from a Chinese cohort.

Gut·2026
See all related articles

Small intestine length grows rapidly before birth, ensuring newborns have adequate gut length. Postnatal growth slows, but significant length variation provides a reserve for gut adaptation to various challenges.

Area of Science:

  • Human Anatomy
  • Developmental Biology
  • Gastroenterology

Background:

  • Small intestinal structure, cytokinetics, and function are key to gut adaptation.
  • Intestinal length provides a reserve for responding to disease, damage, and dietary changes.
  • Understanding small intestinal growth is crucial for neonatal and pediatric care.

Purpose of the Study:

  • To describe small intestinal length from conception to adulthood.
  • To analyze the relationship between small intestinal growth and body length.
  • To investigate the implications of intestinal length variation for gut adaptation.

Main Methods:

  • Meta-analysis of eight published reports.
  • Necropsy measurements of 1010 human small intestines.

Related Experiment Videos

  • Statistical analysis of intestinal length relative to body length and age.

    • Main Results:

    • Mean small intestinal length at term: 275 cm; at 20 years: 575 cm.
    • Prenatal growth followed: intestinal length ∝ body length^(4/3); postnatal growth: intestinal length ∝ body length^(1/2).
    • Postnatal coefficient of variation for intestinal length was 24%, much higher than for body length.

    Conclusions:

    • Rapid prenatal growth ensures adequate intestinal length for newborns.
    • Decelerated postnatal growth and significant length variation provide a 'reserve' for gut adaptation.
    • Intestinal length variation is critical for responding to nutritional demands, disease, and surgical resection.