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Updated: Jul 14, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
Koji Matsuoka1, Chiharu Takita, Tetsuo Koyama
1Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan. koji@fms.saitama-u.ac.jp
Abstract:
A conventional synthesis of alpha-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases.
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