Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conjunctival posttransplantation lymphoproliferative disorder.

R Christopher Walton1, Mihaela M Onciu, Farhan A Irshad

  • 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA. cwalton@utmem.edu

American Journal of Ophthalmology
|May 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ocular Complications in School-Age Children and Adolescents after Allogeneic Bone Marrow Transplantation.

American journal of ophthalmology·2020
Same author

Ocular complications in a young pediatric population following bone marrow transplantation.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2018
Same author

Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2017
Same author

Dematiaceous fungal endophthalmitis: report of a case and review of the literature.

Journal of ophthalmic inflammation and infection·2016
Same author

Thalidomide for recalcitrant nodular scleritis in sarcoidosis.

JAMA ophthalmology·2014
Same author

Successful treatment of pediatric plasmacytoid dendritic cell tumors with a contemporary regimen for acute lymphoblastic leukemia.

Pediatric blood & cancer·2013
Same journal

Performance of the ISOLD Score (Interleukin Score for IntraOcular Lymphoma Diagnosis) in the Diagnosis of Vitreoretinal Lymphoma in Clinical Practice.

American journal of ophthalmology·2026
Same journal

Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

American journal of ophthalmology·2026
Same journal

Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

American journal of ophthalmology·2026
Same journal

Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

American journal of ophthalmology·2026
See all related articles

Posttransplantation lymphoproliferative disorder (PTLD) can affect the conjunctiva, presenting as a rare masquerade syndrome. This case highlights successful treatment of conjunctival PTLD in a pediatric bone marrow transplant patient.

Area of Science:

  • Ophthalmology
  • Oncology
  • Transplantation Immunology

Background:

  • Posttransplantation lymphoproliferative disorder (PTLD) is a rare but serious complication following organ or bone marrow transplantation.
  • Ocular involvement of PTLD is uncommon, often presenting as a diagnostic challenge due to its varied clinical manifestations.

Observation:

  • An 8-year-old boy, 3 months post-bone marrow transplant, presented with bilateral conjunctival masses.
  • Ocular examination revealed enlarged, gelatinous bulbar conjunctiva.

Findings:

  • Conjunctival biopsy confirmed a polymorphous lymphoid infiltrate with atypical immunoblastic lymphoma cells, positive for B-cell markers (CD20, CD79a).
  • Epstein-Barr virus (EBV)-encoded RNA was detected in most cells, indicating EBV-related PTLD.

Related Experiment Videos

  • Treatment involved immunosuppression withdrawal and EBV-specific cytotoxic T lymphocytes, leading to complete resolution of conjunctival lesions within five weeks.

    • Implications:

    • This case expands the known clinical spectrum of ocular PTLD, emphasizing the conjunctiva as a potential site of involvement.
    • Early diagnosis and appropriate management, including targeted immunotherapy, are crucial for favorable outcomes in conjunctival PTLD.
    • Ophthalmologists should consider PTLD in the differential diagnosis of unexplained conjunctival lesions in transplant recipients.