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Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jul 14, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma.

Madeleine Zetterberg¹, Gunnar Tasa, Mona Seibt Palmér

¹Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Mölndal, Sweden. madeleine.zetterberg@gu.se

American Journal of Ophthalmology

|May 26, 2007

Summary

Apolipoprotein E (APOE) gene variations do not appear to be associated with primary open-angle glaucoma (POAG). This study found no link between APOE polymorphisms and POAG risk in patients.

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Last Updated: Jul 14, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Published on: May 25, 2020

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Neuroscience
Ophthalmology
Genetics

Background:

Alzheimer disease (AD) risk is influenced by apolipoprotein E (APOE) polymorphisms.
Primary open-angle glaucoma (POAG) is an age-related neurodegenerative disease.
Investigating shared genetic risk factors between POAG and AD is crucial.

Purpose of the Study:

To examine the association between apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).
To determine if APOE genotype influences POAG susceptibility.

Main Methods:

Retrospective case-control association study design.
Analysis of APOE epsilon 2/epsilon 3/epsilon 4 polymorphisms in 242 POAG patients and 187 controls.
Minisequencing technique employed for genotyping.

Main Results:

No significant difference in APOE epsilon 4 allele frequencies between POAG patients and controls.
APOE genotypes showed similar distribution in both the case and control groups.
The Alzheimer-associated APOE epsilon 4 allele was not found to be a risk factor for POAG.

Conclusions:

APOE polymorphisms are not implicated in the pathogenesis of primary open-angle glaucoma.
The study suggests that if a common mechanism links POAG and Alzheimer disease, it does not involve APOE gene variations.
Further research is needed to explore other potential genetic links between these neurodegenerative conditions.