Related Experiment Video

Updated: Jul 14, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

Outcome of living kidney transplant: pediatric in comparison to adults

M Torkaman1, Z Khalili-Matin-Zadeh, M Azizabadi-Farahani

  • 1Nephrology/Urology Research Center (NURC), Baqiyatallah Medical Sciences University, Tehran, Iran. torkaman.mohammad@gmail.com

Transplantation Proceedings
|May 26, 2007
PubMed

Insights

Pediatric kidney transplant recipients have lower graft survival rates compared to adults, though patient survival remains similar. This highlights challenges in pediatric renal transplantation outcomes.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Pediatric Medicine

Background:

  • Renal transplantation is the optimal treatment for end-stage renal disease in children.
  • Pediatric renal transplantation presents unique challenges for achieving successful outcomes.
  • Long-term outcomes of pediatric versus adult kidney transplant recipients require comparison.

Purpose of the Study:

  • To compare the long-term outcomes of pediatric and adult kidney transplant recipients.
  • To analyze differences in patient and graft survival between pediatric and adult transplant groups.

Main Methods:

  • A cohort of 2631 first living-donor kidney transplant recipients (1982-2002) was analyzed.
  • Patients were divided into pediatric (<=18 years, n=301) and adult (>18 years, n=2330) groups.
  • Groups were matched for immunosuppression and HLA mismatches to compare 5-year survival rates.

Main Results:

  • The 5-year graft survival was significantly lower in the pediatric group (56%) compared to the adult group (68%; P=.015).
  • No significant difference was observed in 5-year patient survival between pediatric (88%) and adult (86%) recipients (P>.05).

Conclusions:

  • Pediatric kidney transplantation is associated with poorer graft survival compared to adult transplantation.
  • Factors contributing to lower pediatric graft survival may include medication adherence, side effects, recurrent disease, and heightened immunoreactivity.
  • Further research into optimizing pediatric transplant protocols is warranted.
Abstract

More Related Videos

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

A Modified Surgical Technique for Kidney Transplantation in Mice10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...