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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
Outcome of renal allografts with multiple arteries
A E Gawish1, F Donia, M Samhan
1Hamed Al-Essa Organ Transplant Center, Kuwait. gawishae@hotmail.com
Background:
Renal allograft transplantation with multiple arteries (MRA) was always avoided as much as possible as it is technically demanding and carries a higher MSK for complications. This was a single-center study to explore the graft outcomes of kidney transplantation with MRA.
Patients And Methods:
We retrospectively reviewed the medical records of 35 patients who received kidney grafts with MRA for the surgical technique, surgical complications, graft function, and graft survival. The results were compared with those achieved in recipients of kidney grafts with a single renal artery (SRA).
Results:
Of 35 grafts, there were 2 renal arteries in 30 grafts, and 3 renal arteries in 5 grafts. In the MRA group, there were 7 instances of surgical complications, the mean serum creatinine levels were 122, 139, and 156 micromol/L at 1 month, 1 year, and 5 years, respectively, and the actuarial graft survival rates were 94.3%, 88.6%, and 83% at 1, 5, and 10 years, respectively. In the SRA group, there were 56 instances of surgical complications, the mean serum creatinine levels were 115, 121, and 141 micromol/L at 1 month, 1 year, and 5 years, respectively, and the actuarial graft survival rates were 93.7%, 88.1%, and 84.4% at 1, 5, and 10 years, respectively.
Conclusion:
Although transplantation of MRA grafts might carry a relatively higher risk for complications, it is justified because it gives results comparable with those achieved in SRA.
Insights
Kidney transplantation using multiple renal arteries (MRA) is feasible and safe, offering comparable graft survival rates to single renal artery (SRA) transplants despite a slightly higher complication risk.
Area of Science:
- Nephrology
- Transplant Surgery
- Urology
Background:
- Kidney transplantation with multiple renal arteries (MRA) has historically been avoided due to technical challenges and perceived higher complication risks.
- This study investigates the outcomes of kidney grafts with MRA.
Purpose of the Study:
- To evaluate the graft outcomes, including surgical complications, graft function, and survival rates, of kidney transplantation utilizing MRA.
- To compare these outcomes with those of kidney transplantation using single renal artery (SRA) grafts.
Main Methods:
- Retrospective review of medical records for 35 patients who received kidney grafts with MRA.
- Surgical techniques, complications, graft function, and survival were analyzed.
- Comparison with a cohort of kidney recipients with SRA grafts.
Main Results:
- The MRA group (35 grafts) experienced 7 surgical complications, with mean serum creatinine levels of 122, 139, and 156 micromol/L at 1 month, 1 year, and 5 years.
- Actuarial graft survival rates for MRA were 94.3% (1 year), 88.6% (5 years), and 83% (10 years).
- The SRA group showed comparable outcomes with 56 complications and similar graft survival rates.
Conclusions:
- Transplantation of kidney grafts with MRA may present a slightly elevated risk of complications.
- However, the graft outcomes are comparable to those achieved with SRA grafts, justifying the use of MRA grafts.
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