Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The myofibroblast: one function, multiple origins.

Boris Hinz1, Sem H Phan, Victor J Thannickal

  • 1Laboratory of Cell Biophysics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Bâtiment SG-AA-B143, Station 15, CH-1015 Lausanne, Switzerland. boris.hinz@epfl.ch

The American Journal of Pathology
|May 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiomic MRI model for predicting the development of worrisome features in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs).

La Radiologia medica·2026
Same author

Targeting Cellular Senescence Enhances Post-Burn Wound Healing in Aged Mice.

Shock (Augusta, Ga.)·2026
Same author

Teaching parathyroid-sparing thyroidectomy: Clinical and educational impact of near-infrared autofluorescence. Results of a retrospective case-control study.

Surgery·2026
Same author

Prognostic factors and survival after recurrence in major salivary gland carcinomas: a multicenter study.

Oral oncology·2026
Same author

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor.

Frontiers in bioscience (Landmark edition)·2026
Same author

Protective Effects of Plant-Based Diets Against Colorectal Carcinogenesis via Modulation of Key Cellular and Molecular Mechanisms: A Comprehensive Review of Evidence.

Current oncology (Toronto, Ont.)·2026

Myofibroblasts are key in wound healing and organ remodeling. This review details their varied origins and roles in lung, liver, and vascular fibrosis, aiding future therapies.

Area of Science:

  • Cell Biology
  • Pathology
  • Biomedical Science

Background:

  • Myofibroblasts play a critical role in wound healing and pathological organ remodeling.
  • Mechanisms of extracellular matrix synthesis and tension production by myofibroblasts are well-understood.

Purpose of the Study:

  • To review myofibroblast accumulation and fibrosis evolution in lung, liver, and atheromatous plaques.
  • To highlight specific features, myofibroblast precursors, and differentiation pathways in each condition.

Main Methods:

  • Literature review focusing on myofibroblast biology in fibrotic diseases.
  • Comparative analysis of myofibroblast origins in lung, liver, and atheromatous plaque formation.

Main Results:

Related Experiment Videos

  • Lung fibrosis: Myofibroblasts primarily originate from resident fibroblasts.
  • Liver fibrosis: Hepatic stellate cells are the main source of myofibroblasts.
  • Atheromatous plaque formation: Media smooth muscle cells are the predominant myofibroblast precursors.

    • Conclusions:

    • Understanding the distinct molecular mechanisms of myofibroblast differentiation is crucial for different fibrotic conditions.
    • This knowledge can inform the development of targeted prevention and therapeutic strategies for organ fibrosis.