Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Airway mechanoreceptor deactivation.

J Guardiola1, M Proctor, H Li

  • 1Dept. of Medicine, Univ. of Louisville, Louisville, KY 40292, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ.

The Journal of biological chemistry·1996
Same author

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha.

The Journal of biological chemistry·1996
Same author

Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization.

Cancer research·1996
Same author

Alternatively spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box.

Oncogene·1996
Same author

Emergence of preferred structures in a simple model of protein folding.

Science (New York, N.Y.)·1996
Same author

Developmental regulation of collagen differential expression in the rabbit bladder.

The Journal of urology·1996
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Pulmonary slowly adapting stretch receptors (SARs) deactivate due to overexcitation. Mechanical lung inflation causes SARs to cease firing, supporting the overexcitation hypothesis for breathing control.

Area of Science:

  • Physiology
  • Respiratory System
  • Neuroscience

Background:

  • Airway sensors are crucial for breathing regulation.
  • Pulmonary slowly adapting stretch receptors (SARs) were observed to deactivate after initial excitation.
  • Overexcitation was proposed as a mechanism for SAR deactivation.

Purpose of the Study:

  • To investigate if mechanical stimulation of SARs leads to deactivation.
  • To determine the relationship between lung inflation pressure and SAR deactivation.
  • To provide evidence for the overexcitation theory of SAR function.

Main Methods:

  • Recording unit activity of SARs in anesthetized rabbits.
  • Applying mechanical lung inflation at various constant pressures.
  • Analyzing SAR responses to sustained lung inflation.

Related Experiment Videos

Main Results:

  • 47 out of 137 recorded SAR units showed deactivation during lung inflation.
  • Higher inflation pressures resulted in earlier SAR deactivation.
  • Deactivation often followed intense initial firing, with some units showing pacemaker switching.

Conclusions:

  • Mechanical stimulation of SARs causes deactivation.
  • Results support the hypothesis that SARs deactivate due to overexcitation.
  • This finding has implications for understanding breathing control mechanisms.