[Complications of low-dose amiodarone].

Area of Science:

• Cardiology
• Endocrinology

Context:

• Amiodarone is an effective antiarrhythmic drug.
• Long-term use of amiodarone can lead to various complications.

Purpose:

• To present complications of low-dose amiodarone therapy.
• To evaluate the safety profile of amiodarone in a long-term setting.

Summary:

• This study analyzed complications in 83 patients on low-dose amiodarone over 1-13 years.
• Thyroid dysfunction (hypothyroidism, hyperthyroidism) was common, alongside mild gastrointestinal and skin reactions.
• No significant liver, nervous system, or cardiac arrhythmic effects were observed; mortality was zero.

Impact:

• Low-dose amiodarone causes manageable complications, with few cases necessitating drug cessation.
• Highlights the need for monitoring thyroid function during amiodarone treatment.
• Provides insights into the long-term safety of amiodarone in clinical practice.