Related Experiment Video
Updated: Jul 14, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Five-millimeter-incision deep lamellar endothelial keratoplasty: one-year results
Natasha Yepes1, Fanny Segev, Michael Hyams
1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Purpose:
To evaluate visual acuity, topography, and endothelial cell density 1 year after deep lamellar endothelial keratoplasty (DLEK) for endothelial dysfunction.
Methods:
This is a prospective, comparative, interventional case series. Thirty-five eyes of 35 patients who had undergone DLEK with a 5-mm incision and had a minimum of 1-year follow-up were included. Main outcome measures were best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), astigmatism, topographic regularity and symmetry, and endothelial cell density.
Results:
: One year postoperatively, BSCVA was 0.33 +/- 0.12 (mean, 20/60; range, 20/40-20/400) compared with 0.15 +/- 0.15 preoperatively (mean, 20/200; range, 20/70-20/800). Six patients did not reach an acceptable visual acuity and were not included in the mean BSCVA, 2 had a primary failure, and the others had preexisting glaucoma or macular disease. Spherical equivalent was -0.04 +/- 1.2 D, refractive astigmatism was 1.76 +/- 1.69 D, surface regularity index was 0.97 +/- 0.54, and surface asymmetry index was 1.25 +/- 0.78 1 year after surgery. Mean endothelial cell count from the donor was 2904 +/- 559 (range, 4694-2111) and 1 year after surgery was 1595 +/- 662 (range, 702-3040), equating to 45% cell loss (range, 15%-77%).
Conclusions:
DLEK is a newer method to replace the endothelium in patients with Fuchs dystrophy. Results showed minimal astigmatism, good topographic parameters, and acceptable visual acuity. Endothelial cell loss at 1 year was significant.
