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Related Experiment Videos

[Captopril-induced liver dysfunction].

C Putterman1, T Livshitz

  • 1Dept. of Internal Medicine A, Hadassah University Hospital, Ein Kerem, Jerusalem.

Harefuah
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Captopril, used for heart failure and hypertension, can rarely cause liver dysfunction. A patient developed fever and abnormal liver tests after starting captopril, which resolved upon discontinuation, highlighting the need for monitoring.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Captopril is a common angiotensin-converting enzyme (ACE) inhibitor prescribed for congestive heart failure and hypertension.
  • Known side effects include cough, neutropenia, and renal injury, with liver dysfunction being a rare occurrence.

Observation:

  • A 71-year-old male patient with acute myocardial infarction developed high fever and progressive liver function test abnormalities (hepatocellular and cholestatic).
  • These symptoms emerged after initiating captopril therapy.

Findings:

  • After excluding other potential causes, captopril was discontinued.
  • The patient's fever and liver dysfunction rapidly resolved following the cessation of captopril.

Implications:

Related Experiment Videos

  • This case highlights a rare but significant adverse effect of captopril on liver function.
  • Periodic laboratory monitoring is recommended for patients receiving ACE inhibitors to detect potential liver injury early.